Posters & Publications (Scroll down for Publications)
Posters
Highly sensitive detection of IDH1 R132H mutations in plasma of glioma patients
Presented at: ISEV 2018 - Barcelona, Spain
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Physical activity as pre-analytical parameter for liquid biopsies
Presented at: ISEV 2018 - Barcelona, Spain
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Exosomal liquid biopsy reveals mRNA and lincRNA biomarkers in early stage breast cancer patient panels
Presented at: AACR 2018 - Chicago, IL
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Performance of a Clinically Validated Urine Exosome Gene Expression Test to Preditct High-Grade Prosate Cancer in Men with a Prior Negative Biopsy
Presented at: ASCO GU - San Francisco, 2018
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Exosome-based Detection of EGFR T790M in Plasma from Non-Small Cell Lung Cancer Patients
Presented at: AACT, EORTC, NCI - Triple meeting (Philiadelphia, 2017)
Authors: Elena Castellanos-Rizaldos1, Dominik G. Grimm2, Vasisht Tadigotla1, Stefan Bentink2, James Hurley1, John Healy1, Patricia L. Neal1, Mia Sher1, Dan Baughman1, Chris Karlovich3, Mitch Raponi2, Anne Krug2, Mikkel Noerholm2, Luis E. Raez4, Johan K. Skog1
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MONITORING OF ALK FUSION AND MUTATIONS IN ADVANCED ALK POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC) PATIENTS
Presented at: IASLC - World Lung (November 2017)
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Radical Protatectomy Outcomes from a Validated Urine Exosome Gene Expression Assay Which Predicts High-Grade (GS7) Prostate Cancer Suggests Utility for Men Enrolled in Active Surveillance
Presented at: American Urology Association (Boston, 2017)
Authors: M Donova, P Torkler, C Bentis, M Noerholm, J Skog, J McKiernan
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Long RNA Sequencing of Human Plasma Exosomes Reveals Full Coverage of Diverse Protein Coding and Long Non Coding RNA
Presented at: American Association for Cancer Research (Washington DC, 2017)
Authors: Sudipto K. Chakrabortty, Vasisht Tadigotla, Michael Valentino, Dalin Chan, Dominik Grimm, Graham J. Brock & Johan Skog
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Performance of a Validate Urine Exosome Gene Expression Assay to Predict High-Grade Postate Cancer Utilizing the 'International Society of Urological Pathology' (ISUP) 2014 Grading System
Presented at: ASCO GU (Orlando, 2017)
Authors: M Donaovan, P Torkler, J Skog, B Tissel, M Noerholm, P Carroll
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A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy
Published in JAMA Oncology, March 2016 (ePrint download coming soon)
View publication
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Association of plasma exosomal mRNA changes with long-term durable response to ipilimumabin metastatic melanoma patients
Presented at: 2016 American Society of Clinical Oncology Annual Meeting (Chicago; June 2016)
Authors: C. Coticchia, R. Sullivan, J. Hurley, D.rence, K. Flaherty, S. Blackmon, G. Brock and J. Skog
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Discovery and validation of a urinary exosome mRNA signature for the diagnosis of human kidney transplant rejection
Presented at: Annual Meeting of International Society for Extracellular Vesicles (Rotterdam, the Netherlands; May 2016)
Authors: J. Hurley, S. Bentink, L. Hu, A. Srivastava, E. Karecci, A.Mihali, D. Gauvin, G. Brock, J. Azzi and J. Skog
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Exosomal RNA based liquid biopsy detection of androgen receptor variant 7 in plasma from prostate cancer patients
Presented at: 2016 American Association for Cancer Research Annual Meeting (New Orleans, LA; April 2016)
Authors: J. Hurley, G. Brock, J. Siddiqui, Rohit Malik, Arul Chinnaiyan, J. Skog
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Exosomal RNA-based liquid biopsy detection of EML4-ALK in plasma from NSCLC patients
Presented at: 2016 National Comprehensive Cancer Network 21st Annual Conference (Hollywood, FL; March 2016)
Authors: K. Brinkmann, J. Emenegger, D. Carbone, J. Hurley, E. Castellanos-Rizaldos, D. Enderle, T. Koestler, A. Spiel, R. Mueller, D. Baughman, G. Brock, V. O’Neill, J. Skog
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Extended analysis of a validated urine-exosome signature to predict high grade prostate cancer on initial biopsy maintains performance across multiple sub-groups
Presented at: 2016 Genitourinary Cancers Symposium, (San Francisco, CA; January 2016)
Authors: M. Donovan, S. Bentink, K, M. Noerholm, V. O’Neill, J. Skog
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A non-invasive urine exosome gene expression assay (ExoIntelliScoreTM Prostate) accurately predicts pathological stage and grade in the prostatectomy specimen
Presented at: 2016 Genitourinary Cancers Symposium, (San Francisco, CA; January 2016)
Authors: M. Donovan, J. Eastham, V. Patel, J. McKiernan, M. Noerholm, S. Belzer, S. Bentink, J. Skog, V. O’Neill
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Early exosome mRNA changes are associated with improved progression free survival of metastatic melanoma patients on ipilimumab: Identification of a novel exosome mRNA signature of ipilimumab response
Presented at: 26th AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, (Boston, Mass.; November 2015)
Authors: C. Coticchia, R. Sullivan, K. Flaherty, J. Hurley, L. Hu, S. Blackmon, G. Brock, V. O’Neill, J. Skog
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Plasma EGFR mutation detection using a combined exosomal RNA and circulating tumor DNA approach in patients with acquired resistance to first-generation EGFR-TKIs
Presented at: 26th AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, (Boston, Mass.; November 2015)
Authors: A.K. Krug, C. Karlovich, T. Koestler, S. Bentink, K. Brinkmann, A. Spiel, J. Emenegger, M. Noerholm, V. O'Neill, L.V. Sequist, JC. Soria, J.W. Goldman, D. Ross Camidge, H.A. Wakelee, S.M. Gadgeel, E. Mann, S. Matheny, L. Rolfe, M. Raponi, D. Enderle, J. Skog
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Profiling exosomal mRNAs in patients undergoing immunotherapy for malignant melanoma
Presented at: 18th European Cancer Congress, (Vienna, Austria; September 2015)
Authors: M. Donovan, J. Eastham, V. Patel, J. McKiernan, M. Noerholm, S. Belzer, S. Bentink, V. O'Neill
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A non-invasive urine exosome gene expression assay (ExoIntelliScore™ Prostate) accurately predicts pathologic stage and grade in the prostatectomy specimen
Presented at: 18th European Cancer Congress, (Vienna, Austria; September 2015)
Authors: J. Hurley, L. Hu, G. Brock, I. Sinclair, R. Sullivan, V. O'Neill, J. Skog, K. Flaherty
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Exosomal RNA-based liquid biopsy detection of EML4-ALK in plasma from NSCLC patients
Presented at: 2015 IASLC 16th World Conference on Lung Cancer, (Denver, Colorado; September 2015)
Authors: K. Brinkmann, J. Emenegger, D. Carbone, J. Hurley, E. Castellanos-Rizaldos, D. Enderle, T. Koestler, A. Spiel, R. Mueller, G. Brock, V. O’Neill, J. Skog, M. Noerholm
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EGFR activating and T790M resistance mutation in plasma exoRNA and cfDNA, detected with single-step isolation columns and targeted resequencing
Presented at: 2015 IASLC 16th World Conference on Lung Cancer, (Denver, Colorado; September 2015)
Authors: A.K. Krug, T. Koestler, D. Enderle, K. Brinkmann, A. Spiel, J. Emenegger, J.J. Wheler , R. Mueller, G. Stoll, S. Bentink, F. Janku, J.Skog, M. Noerholm, V. O’Neill
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Detection of EGFR activating and T790M resistance mutation in plasma of NSCLC patients using combined exosomal RNA and cfDNA capture
Presented at: 16th Annual International Lung Cancer Congress (Huntington Beach, California; July 2015)
Authors: V. J. O’Neill, K. Brinkmann, D. Enderle, T. Koestler, J. Emenegger, A. Spiel, J. Skog, M. Noerholm
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Plasma-Based Monitoring of BRAF Mutations During Therapy for Malignant Melanoma Using Combined Exosomal RNA and Cell-Free DNA Analysis
Presented at: 2015 American Society of Clinical Oncology Annual Meeting (Chicago, Illinois; May 2015)
Authors: R. J. Sullivan, V. J. O’Neill, D. Enderle, M. Valentino, T. Koestler, A. Spiel, S. Blackmon, A. K. Krug, K. Brinkmann, S. Bentink, R. Mueller, J. Emenegger, M. Noerholm, J. Skog, C. Berking, K. Flaherty
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Highly sensitive detection of low abundant somatic mutations in circulating exosomal RNA and cfDNA with next-generation sequencing
Presented at: 2015 American Society of Clinical Oncology Annual Meeting (Chicago, Illinois; May 2015)
Authors: D. Enderle, A. K. Krug, T. Koestler, A. Spiel, J. J. Wheler, K. Brinkmann, J. Emenegger, M. Valentino, S. Bentink, R. Mueller, R. J. Sullivan, K. Flaherty, C. Berking, F. Janku, J. Skog, M. Noerholm, V. J. O’Neill
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Interim performance of a non-DRE urine exosome gene signature to predict Gleason ≥7 prostate cancer on initial prostate needle biopsy from patients enrolled in a prospective observational trial
Presented at: 2015 American Society of Clinical Oncology Annual Meeting (Chicago, Illinois; May 2015)
Authors: M. J. Donovan, M. Noerholm, S. Bentink, S. Belzer, J. Skog, G. A. Brown, J. S. Cochran, V. O'Neill
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Validation of a Novel Non-Invasive Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients Undergoing Initial Biopsy with an Equivocal PSA
Presented at: 2015 American Urological Association Annual Meeting
Presenter: Dr. James McKiernan
View plenary late-breaking abstract presentation.
Plasma-based diagnostics for detection of EML4-ALK fusion transcripts in NSCLC patients
Presented at: 2015 American Association for Cancer Research Annual Meeting (Philadelphia, PA; April 2015)
Authors: K. Brinkmann, D. Enderle, T. Koestler, S. Bentink, J. Emenegger, A. Spiel, R. Mueller, V. O’Neill, J. Sko2, D. Carbone, M. Noerholm
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A first catch, non-DRE urine exosome gene signature to predict Gleason 7 prostate cancer on an initial prostate needle biopsy
Presented at: 2015 Genitourinary Cancers Symposium (Orlando, Florida; February 2015)
Authors: M. J. Donovan, M. Noerholm, S. Bentink, S. Belzer, J. Skog, G. A. Brown, J. S. Cochran, V. O'Neill
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Development of a single-step isolation platform to analyze exosomal RNA and cell-free DNA in plasma from cancer patients
Presented at: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (Barcelona, Spain; November 2014)
Authors: D. Enderle, T. Koestler, A. Spiel, K. Brinkmann, S. Bentink, J. Skog, M. Noerholm
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Monitoring therapy response and resistance mutations in circulating RNA and DNA of plasma from melanoma patients
Presented at: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (Barcelona, Spain; November 2014)
Authors: D. Enderle, T. Koestler, R.J. Sullivan, A. Spiel, K. Brinkmann, R. Mueller, S. Bentink, V. O’Neill, J. Skog, M. Noerholm, C. Berking, K.T. Flaherty
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Circulating miRNAs in Human Plasma
Presented at: The International Society for Extracellular Vesicles (ISEV) Annual Meeting (Rotterdam; April 2014)
Authors: Daniel Enderle, Alexandra Spiel, Tina Koestler, Martin Schlumpberger, Markus Sprenger-Haussels, Jonathan Shaffer, Eric Lader, Johan Skog, Mikkel Noerholm
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Characterization of RNA from extracellular vesicles
Presented at: The International Society for Extracellular Vesicles (ISEV) Annual Meeting (Rotterdam; April 2014)
Authors: Daniel Enderle, Alexandra Spiel, Romy Mueller, Charlotte Romain, Emily Berghoff, Susan Belzer, Stefan Bentink, Martin Schlumpberger, Markus Sprenger-Haussels, Jonathan Shaffer, Eric Lader, Johan Skog, Mikkel Noerholm
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The exoRNeasy Serum/Plasma Maxi Kit for Isolation of RNA from Extracellular Vesicles
Presented on January 30, 2014
Authors: Daniel Enderle, Alexandra Spiel, Romy Müller, Charlotte Romain, Emily Berghoff, Susan Belzer, Tina Koestler, Stefan Bentink, Martin Schlumpberger, Johan Skog, Mikkel Noerholm
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Original Publications
Liquid Biopsies Using Plasma Exosomal Nucleic Acids and Plasma Cell-Free DNA Compared with Clinical Outcomes of Patients with Advanced Cancers
Inflammatory gene expression signatures in idiopathic intracranial hypertension: possible implications in microgravity-induced ICP elevation
Characterization of RNA from Exosomes and Other Extracellular Vesicles Isolated by a Novel Spin Column-Based Method
PLoS ONE 10(8): e0136133; Published online: 28 August 2015
doi: 10.1371/journal.pone.0136133
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136133
Authors: Daniel Enderle, Alexandra Spiel, Christine M. Coticchia, Emily Berghoff, Romy Mueller, Martin Schlumpberger, Markus Sprenger-Haussels, Jonathan, M. Shaffer, Eric Lader, Johan Skog, Mikkel Noerholm
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Liquid biopsy for cancer screening, patient stratification and monitoring
Translational Cancer Research, Vol 4, No 3 (June 2015): 280-290
doi: 10.3978/j.issn.2218-676X.2015.06.05
http://www.thetcr.org/article/view/4546
Authors: Graham Brock, Elena Castellanos-Rizaldos, Lan Hu, Christine Coticchia, Johan Skog
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BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles
Molecular Therapy Nucleic Acids (2013) 2, e109 (23 July 2013)
doi: 10.1038/mtna.2013.28
http://www.nature.com/mtna/journal/v2/n7/full/mtna201328a.html
Authors: Walter W Chen, Leonora Balaj, Linda M. Liau, Michael L. Samuels, Steve K. Kotsopoulos, Casey A. Maguire, Lori LoGuidice, Horacio Soto, Matthew Garrett, Lin Dan Zhu, Sarada Sivaraman, Clark Chen, Eric T Wong, Bob S Carter, Fred H Hochberg, Xandra O. Breakefield and Johan Skog
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RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls
BMC Cancer 2012, 12:22
doi: 10.1186/1471-2407-12-22
Authors: Mikkel Noerholm, Leonora Balaj, Tobias Limperg, Afshin Salehi, Lin Dan Zhu, Fred H Hochberg, Xandra O Breakefield, Bob S Carter and Johan Skog
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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Nature Medicine (2012); Published online: 27 May 2012
doi: 10.1038/nm.2753
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2753.html
Authors: Héctor Peinado, Maša Alečković, Simon Lavotshkin, Irina Matei, Bruno Costa-Silva, Gema Moreno-Bueno, Marta Hergueta-Redondo, Caitlin Williams, Guillermo García-Santos, Cyrus M Ghajar, Ayuko Nitadori-Hoshino, Caitlin Hoffman, Karen Badal, Benjamin A Garcia, Margaret K Callahan, Jianda Yuan, Vilma R Martins, Johan Skog, Rosandra N Kaplan, Mary S Brady, Jedd D Wolchok, Paul B Chapman, Yibin Kang, Jacqueline Bromberg and David Lyden
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Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
Nature Communications 2:180 (2011); Published online: 1 February 2011
doi: 10.1038/ncomms1180
http://www.nature.com/ncomms/journal/v2/n2/full/ncomms1180.html
Authors: Leonora Balaj, Ryan Lessard, Lixin Dai, Yoon-Jae Cho, Scott L. Pomeroy, Xandra O. Breakefield and Johan Skog
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Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease
Kidney International 78, 191–199 (July (2) 2010)
doi: 10.1038/ki.2010.106
http://www.nature.com/ki/journal/v78/n2/full/ki2010106a.html
Authors: Kevin C Miranda, Daniel T Bond, Mary McKee, Johan Skog, Teodor G Păunescu, Nicolas Da Silva, Dennis Brown and Leileata M Russo
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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Nature Cell Biology 10, 1470–1476 (2008); Published online: 16 November 2008
doi: 10.1038/ncb1800
http://www.nature.com/ncb/journal/v10/n12/abs/ncb1800.html
Authors: Johan Skog, Tom Würdinger, Sjoerd van Rijn, Dimphna H. Meijer, Laura Gainche, William T. Curry, Jr., Bob S. Carter, Anna M. Krichevsky and Xandra O. Breakefield
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