Publications
ExoDx prostate test as a predictor of outcomes of high-grade prostate cancer – an interim analysis
Ronald Tutrone, Ben Lowentritt, Brian Neuman, Michael J. Donovan, Elliot Hallmark, T. Jeffrey Cole, Yiyuan Yao, Claire Biesecker, Sonia Kumar, Vinita Verma, Grannum R. Sant, Jason Alter and Johan Skog
Pre‑diagnosis urine exosomal RNA (ExoDx EPI score) is associated with post‑prostatectomy pathology outcome
Alexander Kretschmer, Ronald Tutrone, Jason Alter, Elena Berg, Christian Fischer, Sonia Kumar, Phillipp Torkler, Vasisht Tadigotla, Michael Donovan, Grannum Sant, Johan Skog, Mikkel Noerholm
Exosome-based liquid biopsies in cancer: opportunities and challenges
W. Yu, J. Hurley, D. Roberts, S. K. Chakrabortty, D. Enderle, M. Noerholm, X. O. Breakefield & J. K. Skog
Urine Exosomes for Non-Invasive Assessment of Gene Expression and Mutations of Prostate Cancer
Piruz Motamedinia1, Anna N. Scott, Kendall L. Bate, Neda Sadeghi, Guillermo Salazar, Edan Shapiro, Jennifer Ahn, Michael Lipsky, James Lin, Greg W. Hruby, Ketan K. Badani, Daniel P. Petrylak, Mitchell C. Benson, Michael J. Donovan, Wayne D. Comper, James M. McKiernan, Leileata M. Russo
Validation of a CE‑IVD, urine exosomal RNA expression assay for risk assessment of prostate cancer prior to biopsy
Alexander Kretschmer, Holger Kajau, Eric Margolis, Ronald Tutrone, Tobias Grimm, Matthias Trottmann, Christian Stief, Georg Stoll, Christian A. Fischer, Claudia Flinspach, Anja Albrecht, Lisa Meyer, Tina Priewasser, Daniel Enderle, Romy Müller, Phillipp Torkler, Jason Alter, Johan Skog & Mikkel Noerholm
Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
J Nilsson, J Skog, A Nordstrand, V Baranov, L Mincheva-Nilsson, XO Breakefield and A Widmark
Exosome based analysis for Space Associated Neuro-Ocular Syndrome and health risks in space exploration
Sudipto K. Chakrabortty, Yevgenia L. Khodor, Robert R. Kitchen, Dulaney L. Miller, Kailey M. Babcock, Kyle S. Manning, Steven P. Lang, Vasisht Tadigotla, Wei Yu, Eric Bershad, Johan Skog and Susana Zanello
Inflammatory gene expression signatures in idiopathic intracranial hypertension: possible implications in microgravity-induced ICP elevation
Susana B. Zanello, Vasisht Tadigotla, James Hurley, Johan Skog, Brian Stevens, Eusebia Calvillo and Eric Bershad
The Role of the ExoDx Prostate Test in Early Detection of Prostate Cancer (urologytimes.com)
How I Use It: The Exosome Diagnostics (EPI) prostate cancer biomarker utility in urology and primary care - PubMed (nih.gov)
A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result | Prostate Cancer and Prostatic Diseases
Frontiers | Integrating biomarkers and multi-parametric MRI to provide enhanced clinical diagnosis for prostate cancer (frontiersin.org)
Predicting high-grade prostate cancer at initial biopsy: clinical performance of the ExoDx (EPI) Prostate IntelliScore test in three independent prospective studies
Prostate Cancer And Prostatic Diseases | September 2021
Authors: Margolis E, Brown G, Partin A, Carter B, McKiernan J, Tutrone R, Torkler P, Fischer C, Tadigotla V, Noerholm M, Donovan MJ, Skog J.
A urine-based Exosomal gene expression test stratifies risk of high-grade prostate Cancer in men with prior negative prostate biopsy undergoing repeat biopsy
BMC Urology | September 2020
Authors: McKiernan J, Noerholm M, Tadigotla V, Kumar S, Torkler P, Sant G, Alter J, Donovan M, Skog J.
Clinical utility of the exosome based ExoDx Prostate (IntelliScore) EPI test in men presenting for initial Biopsy with a PSA 2–10 ng/mL
Prostate Cancer and Prostatic Diseases | May 2020
Authors: Tutrone R, Donovan MJ, Torkler P, Tadigotla V, McLain T, Noerholm M, Skog J, McKiernan J
A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2–10 ng/ml at Initial Biopsy
European Urology | September 2018
Authors: McKiernan J, Donovan MJ, Margolis E, Partin A, Carter B, Brown G, Torkler P, Noerholm M, Skog J, Shore N, Andriole G, Thompson I, Carroll P.
A Novel Urine Exosome Gene Expression Assay to Predict High-Grade Prostate Cancer at Initial Biopsy
JAMA Oncology | July 2016
Authors: McKiernan J, Donovan MJ, O’Neill V, Bentink S, Noerholm, M, Belzer Skog J, Kattan MW, Partin A, Andriole G, Brown G, Wei JT, Thompson IM Jr, Carroll P
Extracellular vesicles from plasma have higher tumour RNA fraction than platelets
Journal of Extracellular Vesicles | March 2020
Brinkman K, Meyer L, Bickel A, Enderle D, Berking C, Skog J, Noerholm M
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nature Cell Biology | December 2018
Authors: Skog J, Wurdinger T, van Rijn S, Meijer D, Gainche L, Sena-Esteves M, Curry Jr. WT, Carter RS, Krichevsky AM, Breakefield XO
Liquid Biopsies Using Plasma Exosomal Nucleic Acids and Plasma Cell-Free DNA Compared with Clinical Outcomes of Patients with Advanced Cancers
Clinical Cancer Research | October 2017
Authors: Mӧhrmann L, Huang HJ, Hong DS, Tsimberidou AM, Fu S, Piha-Paul SA, Subbiah V, Karp DD, Naing A, Krug A, Enderle D, Priewasser T, Noerholm M, Eitan E, Coticchia C, Stoll G, Jordan LM, Eng C, Kopetz ES, Skog J, Meric-Bernstam F, Janku F
Liquid biopsy for cancer screening, patient stratification and monitoring
Translational Cancer Research | June 2015
Authors: Brock G, Castellanos-Rizaldos E, Hu L, Coticchia C, Skog J
Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease
Kidney International | July 2010
Authors: Miranda KC, Bond DT, McKee M, Skog J, Păunescu TG, Da Silva N, Brown D, Russo LM
Abstracts
Exosome Biomarker Clinical Impact on Timing and Decision to Have a Prostate Biopsy
Jason Alter PhD, Sonia Kumar PhD, Johan Skog PhD, Vinita Verma MPH, Yiyuan Yao MS, Christian J Ray PhD, Brian Haynes PhD, Laurence Belkoff DO, Ronald Tutrone MD, David J. Cahn, MD, Paul Dato, MD, Jason Hafron, MD, Zachariah Taylor, DO, Scott Serpico, DO, Lan Huynh, BS,
Emily T. Ayre, MS, Claire E. Biesecker, BS, Katayune Golshan, BFA
Utilization of ExoDx Prostate Test for Prostate Cancer Risk Stratification in the African American Population
Ronald Tutrone MD, Sonia Kumar PhD, Christian Ray PhD, Jason Alter PhD, Grannum Sant MD, Yiyuan Yao MS, Vinita Verma MPH, Johan Skog PhD
Exosomal liquid biopsy reveals mRNA and lincRNA biomarkers in early stage breast cancer patient plasma
Sudipto K. Chakrabortty, Robert R. Kitchen, Christine M. Coticchia, Erez Eitan, Michael D. Valentino, Vasisht R. Tadigotla, Elena Castellanos-Rizaldos, Lisa Bedford, Hidefumi Uchiyama,
Sunita Badola, Nicholas Colafemina, Mario Morken, Miguel Williams, Sylvie Vincent, Seth Yu and Johan Skog
Exosomal RNA based liquid biopsy detection of androgen receptor variant 7 in plasma from prostate cancer patients.
James Hurley, Graham Brock, Javed Siddiqui, Rohit Malik, Arul Chinnaiyan, Johan Skog
Discovery and validation of a urinary exosomes mRNA signature for the diagnosis of human kidney transplant rejection
James Hurley, Stefan Bentink, Lan Hu, AnandSrivastava, EsilidaKarecci, AlbanaMihali, Daniel Gauvin, Graham Brock, Jamil Azzi and Johan Skog
Development and Utility of an At Home Urine (EPI) Test Kit During COVID-19 Pandemic to Support Prostate Cancer Diagnosis Shared-decision Making and Telehealth
Ali Kasraeian MD, David Albala, MD, Grannum Sant, MD, Judd Moul, MD, Liam Hurley, MD, Sanoj Punnen, MD, Jason Alter, PhD, Ronald Tutrone, MD
Detection of MISEV recommended EV Protein-Markers using Automated Western Blotting
ISEV | July 2020
Authors: Meyer L, Enderle D, Lück C, Bickel A, Khan Y, Heger C, Schlumpberger M, Sprenger-Haussels M, Skog J, Noerholm M.
Identification of a saliva exosomal RNA signature for Sjogren’s syndrome
ISEV | July 2020
Authors: Sudipto K. Chakrabortty, Yevgenia L. Khodor, Steven P. Lang, Martina Rauscher, Vasisht Tadigotla, Robert R. Kitchen, Mabi Singh, Andrew Hoffman, Athena Papas, Seth Yu, and Johan Skog
Identification of Plasma-Derived, EV-Based Biomarkers for Glioblastoma
ISEV | July 2020
Authors: Yevgenia L. Khodor, Sudipto K. Chakrabortty, Martina Rauscher, Christian A. Fischer, Steven P. Lang, Julia Small, Leonora Balaj, Bob Carter, Seth Yu, and Johan Skog
Urine Exosome Gene Expression Assay Net Benefit Analysis in a Large Cohort (>1200)
ASCO GU | February 2020
Authors: McKiernan J, Tutrone, R, Donovan, M, Torkler, P, Noerholm, M, Alter, J, Skog, J.
Clinical utility of biomarkers 4k score, SelectMDx and ExoDx with MRI for the detection of high-grade prostate cancer
ASCO GU | FEB 2020
Authors: Fasulo V, de la Calle C, Cowan J, Herlemann C, Gadzinski AJ, Yeung RA, Saita A, Cooperberg MR, Shinohara K, Carroll P, Nguyen HG
Performance of a validated urine exosome gene expression test (EPI) in men within the USPSTF suggested age-group of 55 to 69 years at initial biopsy with a PSA 2-10 ng/mL
ASCO | February 2019
Authors: Donovan MJ, Noerholm M, Torkler P, Skog, Margolis E, Brown GA, McKiernan JM
Extended validation results from a prospective adaptive utility trial confirm performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer at initial biopsy.
European Urology | April 2018
Authors: McKiernan J, Donovan MJ, Margolis E, Partin A, Carter B, Brown G, Torkler P, Noerholm M, Bentis C, Skog J, Shore N, Thompson I, Andriole G, Carroll P
Performance of a clinically validated urine exosome gene expression test to predict high grade prostate cancer in men with a prior negative biopsy
Journal Clinical Oncology | 2018
Authors: Donovan MJ, Torkler P, Noerholm M, Skog J, McKiernan JM
Development of a clinical implementation plan (CarePath) for a novel urine exosome gene expression assay as part of a two-cohort, adaptive decision impact utility trial
AUA | May 2018
Authors: McKiernan J, Donovan MJ, Partin A, Carter B, Brown A, Torkler P, Noerholm M, Bentis C, Skog J, Shore N, Andriole G, Etzioni R, Thompson I, Carroll P
Exosomal liquid biopsy reveals mRNA and lincRNA biomarkers in early stage breast cancer patient plasma
AACR | April 2018
Authors: Chakrabortty SK, Kitchen RR, Coticchia CM, Eitan E, Valentino MD, Tadigotla VR, Castellanos-Rizaldos E, Bedford L, Uchiyama H, Badola S, Colafemina N, Morken M, Williams M, Vincent S, Yu S, Danaee H, Skog J
Radical prostatectomy outcomes from a validated urine exosome gene expression assay which predicts high-grade (GS7) prostate cancer suggests utility for men enrolled in Active Surveillance
AUA | May 2017
Authors: Donovan MJ, Torkler P, Bentis C, Noerholm M, Skog J, McKiernan J
Performance of a validated urine exosome gene expression assay to predict high-grade prostate cancer utilizing the ‘International Society of Urological Pathology’ (ISUP) 2014 grading system
ASCO GU | Feb 2017
Authors: Donovan M, Torkler P, Skog, Tisel B, Noerholm M, Carroll P
Performance of a validated urine exosome gene expression assay to predict high-grade prostate cancer utilizing the ‘International Society of Urological Pathology’ (ISUP) 2014 grading system
ASCO GU | Feb 2017
Authors: Donovan M, Torkler P, Skog, Tisel B, Noerholm M, Carroll P