Publications

A urine-based Exosomal gene expression test stratifies risk of high-grade prostate Cancer in men with prior negative prostate biopsy undergoing repeat biopsy

BMC Urology| September 2020
Authors: McKiernan J, Noerholm M, Tadigotla V, Kumar S, Torkler P, Sant G, Alter J, Donovan M, Skog J.

Clinical utility of the exosome based ExoDx Prostate (IntelliScore) EPI test in men presenting for initial Biopsy with a PSA 2–10 ng/mL

Prostate Cancer and Prostatic Diseases | May 2020
Authors: Tutrone R, Donovan MJ, Torkler P, Tadigotla V, McLain T, Noerholm M, Skog J, McKiernan J

A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2–10 ng/ml at Initial Biopsy.

European Urology | September 2018
Authors: McKiernan J, Donovan MJ, Margolis E, Partin A, Carter B, Brown G, Torkler P, Noerholm M, Skog J, Shore N, Andriole G, Thompson I, Carroll P.

A Novel Urine Exosome Gene Expression Assay to Predict High-Grade Prostate Cancer at Initial Biopsy

JAMA Oncology | July 2016
Authors: McKiernan J, Donovan MJ, O’Neill V, Bentink S, Noerholm, M, Belzer Skog J, Kattan MW, Partin A, Andriole G, Brown G, Wei JT, Thompson IM Jr, Carroll P

Extracellular vesicles from plasma have higher tumour RNA fraction than platelets

Journal of Extracellular Vesicles | March 2020
Brinkman K, Meyer L, Bickel A, Enderle D, Berking C, Skog J, Noerholm M

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.

Nature Cell Biology | December 2018
Authors: Skog J, Wurdinger T, van Rijn S, Meijer D, Gainche L, Sena-Esteves M, Curry Jr. WT, Carter RS, Krichevsky AM, Breakefield XO

Liquid Biopsies Using Plasma Exosomal Nucleic Acids and Plasma Cell-Free DNA Compared with Clinical Outcomes of Patients with Advanced Cancers

Clinical Cancer Research | October 2017
Authors: Mӧhrmann L, Huang HJ, Hong DS, Tsimberidou AM, Fu S, Piha-Paul SA, Subbiah V, Karp DD, Naing A, Krug A, Enderle D, Priewasser T, Noerholm M, Eitan E, Coticchia C, Stoll G, Jordan LM, Eng C, Kopetz ES, Skog J, Meric-Bernstam F, Janku F

A molecular signature for PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result.

Prostate Cancer and Prostatic Diseases | September 2015
Authors: Donovan MJ, Noerholm M, Bentink S, Belzer S, Skog J, O’Neill V, Cochran, JS, Brown GA

Liquid biopsy for cancer screening, patient stratification and monitoring.

Translational Cancer Research | June 2015
Authors: Brock G, Castellanos-Rizaldos E, Hu L, Coticchia C, Skog J

Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease.

Kidney International | July 2010
Authors: Miranda KC, Bond DT, McKee M, Skog J, Păunescu TG, Da Silva N, Brown D, Russo LM

Detection of MISEV recommended EV Protein-Markers using Automated Western Blotting

ISEV | July 2020
Authors: Meyer L, Enderle D, Lück C, Bickel A, Khan Y, Heger C, Schlumpberger M, Sprenger-Haussels M, Skog J, Noerholm M.

Abstracts

Identification of a saliva exosomal RNA signature for Sjogren’s syndrome

ISEV | July 2020
Authors: Sudipto K. Chakrabortty, Yevgenia L. Khodor, Steven P. Lang, Martina Rauscher, Vasisht Tadigotla, Robert R. Kitchen, Mabi Singh, Andrew Hoffman, Athena Papas, Seth Yu, and Johan Skog

Identification of Plasma-Derived, EV-Based Biomarkers for Glioblastoma

ISEV | July 2020
Authors: Yevgenia L. Khodor, Sudipto K. Chakrabortty, Martina Rauscher, Christian A. Fischer, Steven P. Lang, Julia Small, Leonora Balaj, Bob Carter, Seth Yu, and Johan Skog

Urine Exosome Gene Expression Assay Net Benefit Analysis in a Large Cohort (>1200)

ASCO GU | February 2020
Authors: McKiernan J, Tutrone, R, Donovan, M, Torkler, P, Noerholm, M, Alter, J, Skog, J.

Clinical utility of biomarkers 4k score, SelectMDx and ExoDx with MRI for the detection of high-grade prostate cancer

ASCO GU | FEB 2020
Authors: Fasulo V, de la Calle C, Cowan J, Herlemann C, Gadzinski AJ, Yeung RA, Saita A, Cooperberg MR, Shinohara K, Carroll P, Nguyen HG

Performance of a validated urine exosome gene expression test (EPI) in men within the USPSTF suggested age-group of 55 to 69 years at initial biopsy with a PSA 2-10 ng/mL

ASCO | February 2019
Authors: Donovan MJ, Noerholm M, Torkler P, Skog, Margolis E, Brown GA, McKiernan JM

Extended validation results from a prospective adaptive utility trial confirm performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer at initial biopsy.

European Urology | April 2018
Authors: McKiernan J, Donovan MJ, Margolis E, Partin A, Carter B, Brown G, Torkler P, Noerholm M, Bentis C, Skog J, Shore N, Thompson I, Andriole G, Carroll P

Performance of a clinically validated urine exosome gene expression test to predict high grade prostate cancer in men with a prior negative biopsy.

Journal Clinical Oncology | 2018
Authors: Donovan MJ, Torkler P, Noerholm M, Skog J, McKiernan JM

Development of a clinical implementation plan (CarePath) for a novel urine exosome gene expression assay as part of a two-cohort, adaptive decision impact utility trial

AUA | May 2018
Authors: McKiernan J, Donovan MJ, Partin A, Carter B, Brown A, Torkler P, Noerholm M, Bentis C, Skog J, Shore N, Andriole G, Etzioni R, Thompson I, Carroll P

Exosomal liquid biopsy reveals mRNA and lincRNA biomarkers in early stage breast cancer patient plasma

AACR | April 2018
Authors: Chakrabortty SK, Kitchen RR, Coticchia CM, Eitan E, Valentino MD, Tadigotla VR, Castellanos-Rizaldos E, Bedford L, Uchiyama H, Badola S, Colafemina N, Morken M, Williams M, Vincent S, Yu S, Danaee H, Skog J

Radical prostatectomy outcomes from a validated urine exosome gene expression assay which predicts high-grade (GS7) prostate cancer suggests utility for men enrolled in Active Surveillance

AUA | May 2017
Authors: Donovan MJ, Torkler P, Bentis C, Noerholm M, Skog J, McKiernan J

Performance of a validated urine exosome gene expression assay to predict high-grade prostate cancer utilizing the ‘International Society of Urological Pathology’ (ISUP) 2014 grading system

ASCO GU | Feb 2017
Authors: Donovan M, Torkler P, Skog, Tisel B, Noerholm M, Carroll P