Targeted sequencing and whole transcriptome sequencing
Currently, most clinically actionable RNA biomarkers are messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs). However, profiling of exosomal RNA has been mostly limited to small RNAs which is a major limitation for biomarker discovery. At ExosomeDx, we have developed a highly reproducible and extremely sensitive long RNA-Seq assay (patent pending) optimized to profile long RNAs in exosomes. Our long RNA-Seq assay routinely detects over 10,000 mRNAs and thousands of lncRNAs that has previously remaining undetectable in exosomes; therefore, tremendously expanding the scope of biomarker discovery.