Cells from healthy and diseased tissues shed billions of exosomes into the blood and other biofluids; the resulting total exosome content is the accumulation of exosomes contributed from all tissue. Only a fraction of these exosomes are derived from a specific cell or tissue type.
For many projects, the total exosome content is an appropriate approach to explore the desired biology or detect a biomarker of interest. However, some projects require that exosomes be enriched from a specific tissue or cell source to focus the analysis on signals coming from targets of interest. Exosome Diagnostics has pioneered an approach to address this need: the Exosome Diagnostics Depletion or Enrichment (EDDE) platform which can enrich exosome subsets directly from biofluids.